ALL my KS3 SCIENCE Revision Quizzes (~US K12 grades 6,7,8)

GCSE-IGCSE-KS4 Science-CHEMISTRY notes & quizzes (~US K12 grades 9-10)

Advanced Level CHEMISTRY GCE AS A2 IB notes and quizzes (~US K12 grades 11-12)

All my GCSE-IGCSE Science-CHEMISTRY etc. syllabus help links

 All my GCE-AS-A2-IB AQA, Edexcel, OCR etc. Advanced Level Chemistry syllabus-specification help links

 Doc Brown's Chemistry Clinic

My unofficial support for Salters A2 Advanced Chemistry

Salters A2 Chemistry -  MD "Medicines by Design"

Unit map and learning objectives list - part of module 2854

Exam bashing MD * My revision index * extra MD backup stuff * My Salters A2 homepage * Email

At the moment the AS/A2 links are for the old syllabus * My NEW Salters AS Chemistry page

http://www.york.ac.uk/org/seg/salters/chemistry/word/Organicexercise1.doc (matching structure and functional group exercise)

http://www.york.ac.uk/org/seg/salters/chemistry/word/MDrevision.doc (a splendidly massive 761 Kb WORD organic synthesis exercise)

PLEASE REMEMBER, THESE ARE NOT 'STAND ALONE' NOTES, and were designed for my classes for use alongside the Salters resources - Chemical Ideas, Chemical Storylines, Practical Activities-Investigations and the AS-A2 Revision guides all published by Heinemann Secondary Series, to reduce the reading workload and offer a study strategy. From your teacher (not me!), its handy to have the answers to the Chemical Ideas, Storylines Assignments and Activities Questions side by side with the texts and these strategy pages. You haven't time to redo the Q's but a quick read of the Q's and connecting with the official answers is valuable revision.

MD1.2 BAC determination using gas-liquid chromatography

It is really important to KEEP CI, CS and Activities in strict PARALLEL!!! and not too much of the alcohol just before exams!!!

14.1 Planning a synthesis

14.2 Summary of organic reactions 

7.6 Chromatography (revision)

6.4 Infrared spectroscopy (revision)

MD3.2 Classifying reactions

MD3.3 Using the toolkit to synthesise medicines

MD3.4 Manufacturing salbutamol

6.6 NMR (revision)

6.8 uv and visible spectroscopy (rev)

MD5.2 A closer look at the structure of penicillin's

Unit MD Learning Outcomes

KEY: CS = Chemical storylines, CI = Chemical Ideas, Act = Activity: be able to

1. O know the meaning of the terms: drug, medicine, molecular recognition, pharmocological activity, pharmacophore, receptor site, agonist, antagonist, lead compound [CS MD in general]
2. O show awareness of the chemical principles behind methods which can be used to detect ethanol in the body (g.l.c. and i.r. spectroscopy) [CS MD 1 Ass 2/3/4; Act MD 1.2; CI 6.4/7.6]
3. O describe the following reactions involving aldehydes and ketones: (i) formation by oxidation of alcohols*, (ii) oxidation to carboxylic acids*, (iii) reduction to alcohols and (iv) reaction with hydrogen cyanide [Act MD 1.1; CI 13.2/13.4/13.7] * usually with hot potassium dichromate(VI) and dilute sulphuric acid and watch out for colour changes and Q's with half-cell equations => full ionic/redox reaction equation questions.
4. O explain the mechanism of the nucleophilic addition reaction between an aldehyde or a ketone and hydrogen cyanide [CI 13.7]
5. O describe the structure of a pharmacologically active material* in terms of its functional components: pharmacophore and groups which modify the pharmacophore [CS MD 2/3; Act MD 5.2]
6. O relate the action of biologically active chemicals* to their interaction with receptor sites [CS MD 2/3/4/5 Ass 5/7/8/10/13; Act MD 5.2; CI 13.9]
7. O discuss the factors affecting the way that species interact in three dimensions*: (i) size, (ii) shape, (iii) bond formation and (iv) orientation; [CS MD 2/3/4/5 Ass 7/8/10/13; Act MD 5.2] * for LO's 5. to 7. the concept of geometrical or optical isomerism may be involved.
8. O show awareness of the role of chemists in designing and making new compounds for use as pharmaceuticals [CS MD 3/4/5; Act MD 5.2]
9. O show awareness of the application of computer modeling techniques in the design of medicines [CS MD 4]
10. O identify individual functional groups within a polyfunctional molecule, and hence make predictions about its properties [CS MD 3 Ass 6/8] Quick review of most functional groups and organic nitrogen compounds
11. O use knowledge of organic reactions mentioned elsewhere in these specifications (AS and A2), together with any further given reactions, to devise synthetic routes for preparing organic compounds* [CS MD 5 Ass 11; Act MD 3.1/3.3/3.4/5.1; CI 14.1/14.2] * for LO's 8, 9, 10, 11 and 13 beware of isomer or non-isomer useful co-products or wasteful by-products.
12. O use the following terms to classify organic reactions*: (i) hydrolysis, (ii) oxidation, (iii) reduction, (iv) condensation, (v) elimination [Act MD 3.2; CI 14.1/14.2] * see LO 13.
13. O classify organic reactions according to their reactions mechanisms:  (i) nucleophilic substitution, (ii) electrophilic addition, (ii) electrophilic substitution, (iv) nucleophilic addition, (v) free radical (could be substitution or polymerisation etc.) [CS MD 3.2; CI 14.1/14.2]
14. O use a combination of spectroscopic techniques (mass spec., i.r., n.m.r. and u.v. and visible) to elucidate the structure of organic molecules* [Act MD 3.3/3.4; CI 6.4/6.5/6.6/6.8]* this LO is mostly likely to come in conjunction with LO's 5, 8, 10, 11 or 15.
15. O describe some basic organic preparation, separation and purification techniques* [MD5] * including annotated diagrams of: reflux, distillation, separating funnel, Buchner funnel (reduced pressure filtration), cracking type experiment, and for purity 'testing' melting point, volumetric titration and paper/thin layer chromatography

GENERAL REVISION NOTES

 * Salters Advanced Level Chemistry * Salters Advanced Level Chemistry * Salters Advanced Level Chemistry * Salters Advanced Level Chemistry * Salters Advanced Level Chemistry *